一次意外中，威尔（杰克·尼科尔森 Jack Nicholson 饰）驾车撞倒了一只野狼，当他下车查看情况时，野狼咬伤了威尔。威尔并没有将受伤当成一回事，可自从事故发生以来，一些奇怪的变化开始出现在了威尔的身上，他的感官变得异常灵敏，脾气也愈发暴躁，所有的迹象都在显示，威尔似乎在慢慢的变成一只狼。 动物研究专家亚历齐亚斯（欧姆·普瑞 Om Puri 饰）证实了威尔的疑虑，他给了威尔一张护身符，它能够暂时帮助威尔控制自己的野性。威尔的妻子夏洛特（凯特·尼利甘 Kate Nelligan 饰）死了，死于喉咙被撕裂，威尔的朋友劳拉（米歇尔·菲佛 Michelle Pfeiffer 饰）为威尔做出了不在场证明，而当劳拉身陷险境之时，威尔也毫不犹豫的变成了狼人，出手相救。收起
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