一场可怕的车祸让克莱尔（詹妮弗·安妮斯顿 Jennifer Aniston 饰）不仅容貌尽毁，还失去了挚爱的儿子，之后，深陷于绝望和痛苦中无法自拔的克莱尔患上了慢性疼痛症。为了同疾病做斗争，克莱尔来到了慢性疼痛俱乐部，通过和病友们的相互交流与鼓励，获得生活下去的信心和希望。 妮娜（安娜·肯德里克 Anna Kendrick 饰）是俱乐部中的一员，某日，她自杀身亡的消息震惊了克莱尔。克莱尔想方设法寻求妮娜自杀的真相，最后甚至陷入了同妮娜对话的幻觉之中无法自拔，与此同时，妮娜的丈夫罗伊（萨姆·沃辛顿 Sam Worthington 饰）亦出现在了克莱尔的身旁，将克莱尔卷入了一个又一个漩涡之中。收起
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